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Key practice points
- Metformin is the first-line pharmacological treatment for patients with type 2 diabetes and initiation should be strongly
considered at diagnosis
- In general, treatment intensification is appropriate for patients whose HbA1c levels do not meet, or
closely approach, an agreed target within three months
- Isophane is the fist-line insulin and should be considered for any patients with HbA1c levels persistently
above agreed targets (especially HbA1c > 65 mmol/mol)
- Well-controlled blood pressure is associated with substantial reductions in cardiovascular risk in patients with type
2 diabetes, and should be a focus of care
Lifestyle, education and intensifying treatment
A healthy lifestyle is the foundation of treatment for all people with type 2 diabetes. If agreed lifestyle goals are
not achieved, discussions should be initiated to help overcome barriers to change, regardless of diabetes duration or
type of medicine being taken.
Education is a cornerstone of care
Structured diabetes education is recognised in New Zealand as a critical aspect of treatment.1 The goal
is to enable patients to take an active role in their own care.1 An HbA1c target of 50 – 55
mmol/mol can be explained as the “speed-limit” for patients, i.e. measurements above this level are increasingly unsafe.2 However,
glycaemic targets need to take into account diabetes duration, the presence of co-morbidities, life expectancy, social
circumstances and the personal beliefs and priorities of the patient.3
Intensifying diabetes treatment with oral medicines
Regular review is essential for improving glycaemic control in all patients with diabetes. Treatment adherence should
be assessed in patients who are unable to meet glycaemic targets. In general, intensification is appropriate if the patient’s
HbA1clevels do not meet, or closely approach, an agreed target within three months.2, 3
Metformin is the first-line pharmacological treatment for patients with type 2 diabetes because it is safe,
effective, does not cause weight gain and provides patients with additional cardiovascular benefits.2 There
is a low threshold for initiation and metformin should be started at diagnosis, or soon after, for all patients with type
2 diabetes, unless there are contraindications.3 New Zealand guidelines recommend trialling lifestyle modification
for three months in asymptomatic patients before beginning treatment with metformin.2 In practice, however,
treatment with metformin may often be initiated at diagnosis for these patients.
A sulfonylurea can be added to metformin for patients who have not reached an agreed HbA1c target with
metformin alone.2 Caution is required if a sulfonylurea is prescribed to an older patient or a patient with
reduced renal function, due to the risk of hypoglycaemia.4 Weight-gain is a common adverse effect of treatment
with sulfonylureas.4
Acarbose can be used as a first-line treatment for patients with type 2 diabetes where metformin or a sulfonylurea
are contraindicated or not tolerated, or as an adjunctive treatment for patients taking metformin, a sulfonylurea
or insulin.2, 5 Acarbose is not widely used, however, as it is only mildly effective and is associated with
significant gastrointestinal adverse effects.3
Pioglitazone may be appropriate when treatment with metformin and a sulfonylurea is not tolerated or contraindicated,
or if an alternative to insulin is required.2 Pioglitazone may also be used in combination with metformin
and a sulfonylurea, or as an adjunctive treatment with metformin in patients who require escalating doses of insulin.3 Pioglitazone
use can cause significant weight gain and peripheral oedema, and the risk of heart failure is increased.3 There
is also an increased risk of bone fracture, particularly in post-menopausal females taking pioglitazone.4 Pioglitazone
is contraindicated in patients with a history of heart failure, un-investigated macroscopic haematuria or bladder cancer.4
Initiating insulin treatment
Insulin has a greater blood glucose lowering ability than any other hypoglycaemic medicine and it is eventually required
by many people with type 2 diabetes.6 However, a reluctance to initiate insulin, by both patients and clinicians,
often delays treatment.6 Initiation of insulin in primary care should be considered for any patients with
HbA1c levels persistently greater than their individualised target (especially if HbA1c is > 65
mmol/mol) despite optimal oral treatment,2 particularly if they have signs such as ketonuria and weight loss.6
Isophane is the first-line insulin taken either once daily at night or before breakfast, or twice daily.2
The initial insulin dose is a starting point which should be titrated until the agreed glycaemic level is reached or
hypoglycaemia limits further increases.
New Zealand guidelines recommend that treatment with a sulfonylurea be withdrawn in patients taking twice daily isophane.2 However,
in practice metformin and sulfonylureas are generally continued throughout treatment with basal insulin. When insulin
treatment is intensified to include a short-acting insulin, e.g. with meals, sulfonylureas are withdrawn.
Managing risk factors with regular follow-up
People with type 2 diabetes are three times more likely to die of a cardiovascular event compared with the general population.7 While
good glycaemic control improves microvascular outcomes, e.g. retinopathy, it does not appear to improve cardiovascular
outcomes to the same extent.8 Therefore glycaemic control is part of a wider suite of interventions for patients
with type 2 diabetes, including blood pressure control, lipid management and, if appropriate, smoking cessation and antiplatelet
treatment.3
Pharmacological treatment is recommended for patients with type 2 diabetes with a blood pressure > 130/80 mmHg for
three months, despite changes in lifestyle.2 An ACE inhibitor is the preferred antihypertensive for patients
with type 2 diabetes; or an angiotensin II receptor blocker (ARB) if an ACE inhibitor is not tolerated.2 Systolic
blood pressure < 120 mmHg in people with type 2 diabetes is associated with an increased risk of hypotension, syncope
and cardiac dysrhythmias.9
Measure the albumin:creatinine ratio (ACR) at least annually for people with type 2 diabetes and more frequently
for Māori, Pacific and South Asian peoples.2 Microalbuminuria is the earliest sign of chronic kidney disease
(CKD) in people with diabetes and requires prompt treatment.2
Consider initiating a statin for patients with a five-year cardiovascular risk of >10%.10 People
with type 2 diabetes often have elevated serum triglycerides, decreased HDL cholesterol levels and normal to elevated
LDL cholesterol levels.8
Encourage patients with type 2 diabetes to carefully inspect their feet as part of their daily routine or
ask a family member to do so. The patient’s feet should be clinically assessed at least once a year, or every three months
if they are at high risk of foot complications.2
Patients with type 2 diabetes require retinal testing at least every two years.2 Testing is
performed more frequently if the patient has been diagnosed with retinopathy.2
Be vigilant for mental health problems in patients with type 2 diabetes. Depression is reportedly twice
as common, compared with people in the general population.11 Poor mental health makes it more likely that
patients will not adhere to treatment or attend consultations, increasing their risk of diabetes-related complications
and reducing quality of life.11
For further information, see: “Managing patients with type 2 diabetes:
from lifestyle to insulin”, BPJ 72 (Dec, 2015).
References
- Ministry of Health (MoH). Quality standards for diabetes care toolkit. 2014. Available from:
www.health.govt.nz/system/files/documents/publications/quality-standards-for-diabetes-care-toolkit-2014-nov14-v2.pdf (Accessed Dec, 2015).
- New Zealand Guidelines Group. New Zealand Primary Care handbook 2012. 3rd ed. 2012. Available from:
www.health.govt.nz/publication/new-zealand-primary-care-handbook-2012 (Accessed Dec, 2015).
- Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered
approach. Update to a position statement of the American Diabetes Association and the European Association for the Study
of Diabetes. Diabetes Care 2015;38:140–9. http://dx.doi.org/ 10.1007/s00125-014-3460-0
- New Zealand Formulary (NZF). NZF v42. 2015. Available from: www.nzf.org.nz (Accessed Dec, 2015).
- Mylan New Zealand Ltd. New Zealand data sheet: ACCARB. 2014. Available from:
www.medsafe.govt.nz/profs/datasheet/a/accarbtab.pdf (Accessed Dec, 2015).
- Powers A. Chapter 344: Diabetes mellitus. In: Harrision’s principles of internal medicine. McGraw Hill Medical, 2012.
2968–3002.
- Taylor KS, Heneghan CJ, Farmer AJ, et al. All-cause and cardiovascular mortality in middle-aged people with type
2 diabetes compared with people without diabetes in a large U.K. primary care database. Diabetes Care 2013;36:2366–71.
http://dx.doi.org/ 10.2337/dc12-1513
- Fox CS, Golden SH, Anderson C, et al. Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes
Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes
Association. Diabetes Care 2015;38:1777–803. http://dx.doi.org/10.2337/dci15-0012
- ACCORD Study Group, Cushman WC, Evans GW, et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus.
N Engl J Med 2010;362:1575–85. http://dx.doi.org/10.1056/NEJMoa1001286
- Cardiovascular disease risk assessment: updated 2013 – New Zealand Primary Care Handbook 2012. 2013. Available from:
www.health.govt.nz/system/files/documents/publications/cardiovascular-disease-risk-assessment-updated-2013-dec13.pdf (Accessed Dec, 2015).
- Ducat L, Philipson LH, Anderson BJ. The Mental Health Comorbidities of Diabetes. JAMA 2014;312:691.
http://dx.doi.org/10.1001/jama.2014.8040