Table 2. Dosing protocol when antibiotics are indicated for AOM.16, 17
| Dose |
First line: amoxicillin |
15 mg/kg/dose, three times daily, for five days; OR
30 mg/kg/dose, three times daily, for seven days in severe or persistent infection*
Do not exceed the maximum dose of amoxicillin:
- Neonate aged seven to 28 days – 125 mg/dose
- Child aged one month to 18 years – 1 g/dose
|
If penicillin allergy or intolerance to amoxicillin: erythromycin |
10 – 12.5 mg/kg/dose, four times daily, for five to seven days (maximum 1.6 g/day, however, in severe infections, to a maximum of 4 g/day) |
Alternative: trimethoprim + sulfamethoxazole† |
24 mg/kg/dose (to maximum of 960 mg/dose), twice daily, for five to seven days |
*If infection has not resolved after high dose amoxicillin, expert opinion is that amoxicillin + clavulanic acid can be considered
†Formerly referred to as co-trimoxazole. Oral liquid 40 + 200 mg/5 mL; now expressed as the total dose of trimethoprim + sulfamethoxazole (ratio 1:5) – 240 mg/5 mL oral liquid. Avoid in infants aged under six weeks, due to the risk of hyperbilirubinaemia.16